(176) Mortality and Readmission Rates in Sepsis With Shock: Five-Year Data

Monday, February 24, 2025

11:30am – 12:30pm Eastern Time

Location: Connections Central - RST 04

First Author(s)

JG

Jayant Gupta, N/A

Undergraduate Student
Cornell University, United States

Co-Author(s)

AR

Adishwar Rao, MD

Resident Physician
Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, PA, Texas, United States
Akriti Agrawal, M.B.B.S.

Guthrie Robert Packer Hospital, Pennsylvania, USA
BA

Bindu Akkanti, MD,

University of Texas Health Science Center At Houston, United States

Introduction: Sepsis continues to be a leading cause of morbidity and mortality in the intensive care units around the country. We analyzed the Nationwide Readmissions Database from 2016-2020 to evaluate the characteristics, outcomes and readmission rates of septic shock patients.

Methods: The total weighted sample size for septic shock index admissions was 2,910,403. Descriptive statistics and multivariate analysis were used to determine factors associated with mortality and readmission rates.

Results: The mortality rate among septic shock patients was 33.5% (973,604 patients), while 66.5% (1,936,799 patients) survived. Mortality was higher in males (53.3%) compared to females (46.7%). The mean age of deceased patients was higher than that of survivors (71 years vs. 67 years, p < 0.001). The median length of stay was shorter for deceased patients (6 days) compared to survivors (9 days, p < 0.001). Most patients had Medicare as their primary insurance (69.1% of deceased vs. 65.1% of survivors). The prevalence of comorbidities such as hyperlipidemia, hypertension, chronic heart failure, obesity, COPD, liver disease, CKD/ESRD, and diabetes was higher among survivors. In contrast, smokers, those with obstructive sleep apnea, and patients with COVID-19 were more common among those who died.

Conclusions: The overall readmission rate continues to be about 20% in patients with Sepsis with shock. The top causes of readmission are Sepsis (75%), line infections (6%), NSTEMI (0.4%), and aspiration pneumonia (O.32%). Our study suggests that interventions where we can focus on decreasing readmissions will likely lead to better outcomes in this patient population.