This presentation offers a thorough examination of advanced radiographic imaging modalities tailored for the rapid and precise diagnostic evaluation of fevers of unknown origin (FUO) in critically ill patients. Attendees will gain a comprehensive understanding of the specific nuances of contrast-enhanced imaging techniques, including computed tomography (CT) scans, fluorodeoxyglucose-positron emission tomography (FDG-PET) scanning, and magnetic resonance imaging (MRI). The presenter will delve into the unique advantages and clinical applications of each modality, providing attendees with practical insights into optimizing diagnostic accuracy while ensuring patient safety. The presentation will highlight the emerging role of the newer bedside ultrasound devices for imaging as a valuable adjunctive tool for directed diagnostic evaluation of FUO. Attendees will learn how bedside ultrasound facilitates real-time visualization of anatomical structures and enables targeted assessment of potential infectious foci, enhancing diagnostic precision and expediting clinical decision-making at the point of care. By integrating advanced radiographic imaging techniques and bedside ultrasound imaging, this presentation will equip healthcare professionals with the knowledge and skills necessary to effectively navigate the diagnostic challenges associated with fevers of unknown origin in critically ill patients, ultimately improving patient outcomes in the critical care setting.